The Pa-O settled in the Thaton region of present-day Myanmar about 1000 B.C. Historically, the Pa-O wore colorful clothing, until King Anawratha defeated the Mon King Makuta, who had established his reign in Thaton. The Pa-O were enslaved, and forced to wear indigo-dyed clothing, to signify their status. However, there are regional variations of clothing among the Pa-O. Many have adopted Bamar clothing, while men may wear Shan baung-mi (long baggy pants). The majority of Pa-O are Buddhists, but a written language was created by Christian missionaries. The Pa-O predominantly engage in agriculture, cultivating leaves of the thanapet tree and mustard leaves. The Pa-O have largely assimilated into Bamar society, adopting many Bamar traditions and wearing Bamar clothing.
One of the most well-known of the Pa-O is Kyaing Kyaing, the wife of Burmese head of state, Than Shwe.