He was the Democratic Party's candidate for governor in the 1908 Utah election. He served as assistant secretary of the treasury from 1917-1921 in the administration of Woodrow Wilson, the first memember of The Church of Jesus Christ of Latter-day Saints to be appointed to a subcabinet position.
In From 1928 to 1933 he served as president of the Eastern States Mission of The Church of Jesus Christ of Latter-day Saints. This mission then covered New York, Pennsylvania, West Virginia, Maryland, Delaware the District of Columbia, Connecticut, Massachusetts, Rhode Island and New Jersey. During his adminstiration West Virginia and Western Maryland were separated off into the East Central States Mission.
Moyle died in 1946. Mormon leader Henry D. Moyle was his son.