The sculpture depicted in the cover art, "Life Support 1993", was designed by H.R. Giger, and is in fact un update of a sculpture he created in the late 1960s. The video for the song "Heartwork" features a real-life interpretation of the sculpture, including a human welded as a part of it. The album is back in print for the first time in years following the June 2 2008 Dualdisc reissue.
Michael Amott left the band after the recording of the album before founding Spiritual Beggars, and was temporarily replaced by Mike Hickey. In The Pathologist's Report, Bill Steer says Heartwork is his favourite Carcass album.
The album was rereleased in 2008 as part of an ongoing series of Carcass reissues to tie in with their reunion. The main album is presented as one side of a Dualdisc, while the DVD side features the fourth part of an extended interview/documentary titled The Pathologist's Report Part IV: Epidemic. Also included in the reissue is a bonus disc including the entire album in demo form, something recorded by the band before recording the actual album in an effort to be better prepared. The demo features the same 10 songs in a slightly different order. The album is presented in a 12-panel digipak with full lyrics and artwork.