Francis served as president of the Antigua and Barbuda Union of Teachers from 1995 to 1998. On 27 March 2004 she was appointed to the Senate. She served as Vice President of the Senate in 2004–05, and was elected President of the Senate on 7 January 2005.
On 28 October 2005, she was violently attacked, robbed, and raped in her home, and was briefly hospitalised as a result. The incident served to intensify the debate around high levels of crime and prompted a review of security arrangements for government officials.