She is a syndicated columnist appearing in the New York Post and other newspapers around the country. In 1960 she covered the Nixon-Kennedy debates as a television critic for the Scripps-Howard newspaper chain. Her work landed her on the master list of Nixon political opponents.
Van Home had to deal with prevailing sexism against female journalists. Ray Erwin of Editor & Publisher described syndicated columnist Harriet Van Home as "a dainty, blue-eyed blonde with a sweet-voiced feminine manner-and a harpoon in her typewriter."