First led by former Union General Samuel C. Armstrong, among the school's famous alumni is educator Dr. Booker T. Washington. Under what is now called the Emancipation Oak tree, Mary Smith Peake taught the first classes on September 17, 1861, in defiance of a Virginia law against teaching slaves, free blacks and mulattos to read or write, a law which had cut her own education short years earlier. Several years later, U.S. President Abraham Lincoln's Emancipation Proclamation was read to local freedmen under the same historic tree, which is still located on the campus today, and also serves as a symbol for the modern City of Hampton.
Hampton University rock can trace its roots to the work of Mary S. Peake of Norfolk which began in 1861 with outdoor classes taught under the landmark Emancipation Oak in the nearby area of Elizabeth City County adjacent to the old sea port of Hampton. The newly-issued Emancipation Proclamation was first read to a gathering under the historic tree there in 1863.
Typical of traditionally Indian, Mulatto and Black colleges and universities, Hampton received much of its financial support in the years following the Civil War from church groups and former officers and soldiers of the Union Army. One of the many Civil War veterans who gave substantial sums to the school was General William Jackson Palmer, a Union cavalry commander from Philadelphia, who later built the Denver and Rio Grande Western Railroad, and founded Colorado Springs, Colorado. As the Civil War began in 1861, although his Quaker upbringing made Palmer abhor violence, his passion to see the slaves free compelled him to enter the war. He was awarded the Medal of Honor for bravery in 1894. (The current Palmer Hall on the campus is named in his honor.)
Unlike the wealthy Palmer, Sam Armstrong was the son of a missionary to the Sandwich Islands (which later became the U.S. state of Hawaii). However, he also had dreams and aspirations for the betterment of the newly freed slaves. He patterned his new school in the manner of his father, who had overseen the teaching of reading, writing and arithmetic to the Polynesians. He also felt it was important to add the skills necessary to be self-supporting in the impoverished South. Under his guidance, a Hampton-style education became well-known as an education that combined cultural uplift with moral and manual training, or as Armstrong was fond of saying, an education that encompassed "the head, the heart, and the hands."
At the close of its first decade, the school reported a total admission in the ten years of 927 students, with 277 graduates, all but 17 of whom had become teachers. Many of them had bought land and established themselves in homes; many were farming as well as teaching; some had gone into business. Only a very small proportion had failed to do well. By another 10 years, there had been over 600 graduates. In 1888, of the 537 of them alive, three-fourths were teaching, and about half as many undergraduates were also currently teaching. It was estimated that 15,000 children in community schools were being taught by Hampton's students and alumni that year.
The school is informally called simply "Hampton" or "HU" by many students, faculty and supporters. Students informally refer to the school as "HIU", or Hampton Institute and University. The "Institute" refers to the undergraduate program, while the "University" is the graduate program. Hampton and Howard University constantly claim the title, "The Real HU". (Hampton Institute became "Hampton University" in 1984.)
The original Phenix High School on the campus became Phenix Hall when Hampton City Public Schools opened a new Phenix High School in 1959. Phenix Hall received minor fire damage on June 12, 2008.
The Emancipation Oak was cited by the National Geographic Society as one of the 10 great trees in the world.
In addition, although Cleveland Hall, Ogden, and the Administration building have less historical significance, they are also included in the district.
The district was listed on the National Register of Historic Places in 1969, and was further declared a National Historic Landmark in 1974.
Rivals include Norfolk State University, located across Hampton Roads in downtown Norfolk, and Howard University in Washington, D.C.
Hampton's colors are blue and white, and their nickname is the "The Pirates". Hampton sports teams participate in NCAA Division I (I-AA for football) in the Mid-Eastern Athletic Conference (MEAC) in which they joined in 1995 after leaving the Central Intercollegiate Athletic Association. Since joining, Hampton has won MEAC titles in many sports, including football, men's and women's basketball, men's and women's track, and men's and women's tennis. In 2001, the Hampton basketball team won its first NCAA Tournament game, when they beat Iowa State 58–57, in one of the largest upsets of all time.
They won their conference in football in 1997, shared one in 1998 and 2004, and one the conference out right in 2005, 2006. From 2004 to 2007, the university's football team saw much success. The team won 3 MEAC Championships, 3 SBN-Black College National Championships, and was ranked in the Division I FCS top 25 poll each year. The Pirates also sent five players to the NFL Combine in 2007, the most out of any collegiate school for that year. They have also been dominant in tennis winning the MEAC in 1996, 1997, 1998, 1999, 2001, 2002, 2003, 2007 for the men and 1998, 2002, 2003, 2004 for the women. They've also won the men's conference basketball tournament in 2001, 2002, 2006 and the women's tournament in 2000, 2003, 2004.