HDMP-28 is a piperidine based stimulant drug. It is closely related to dexmethylphenidate, but with the phenyl ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, (-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate.

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