Guanylate kinase

ATP + GMP $rightleftharpoons$ ADP + GDP

Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(d)GMP phosphotransferase. Other names in common use include deoxyguanylate kinase, 5'-GMP kinase, GMP kinase, guanosine monophosphate kinase, and ATP:GMP phosphotransferase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , and .

References

• Buccino RJ Jr, Roth JS "Partial purification and properties of ATP:GMP phosphransferase from rat liver". Arch. Biochem. Biophys. 132 49–61.
• Hiraga S, Sugino Y "Nucleoside monophosphokinases of Escherichia coli infected and uninfected with an RNA phage". Biochim. Biophys. Acta. 114 416–8.
• Griffith TJ, Helleiner CW "The partial purification of deoxynucleoside monophosphate kinases from L cells". Biochim. Biophys. Acta. 108 114–24.
• Oeschger MP, Bessman MJ "Purification and properties of guanylate kinase from Escherichia coli". J. Biol. Chem. 241 5452–60.
• Shimono H, Sugino Y "Metabolism of deoxyribonucleotides. Purification and properties of deoxyguanosine monophosphokinase of calf thymus". Eur. J. Biochem. 19 256–63.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes