glycolate + NAD⁺ $rightleftharpoons$ glyoxylate + NADH + H⁺

Thus, the two substrates of this enzyme are glycolate and NAD⁺, whereas its 3 products are glyoxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NAD+ oxidoreductase. Other names in common use include NADH-glyoxylate reductase, glyoxylic acid reductase, and NADH-dependent glyoxylate reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

References

• Zelitch I "Oxidation and reduction of glycolic and glyoxylic acids in plants II. Glyoxylic acid reductase". J. Biol. Chem. 201 719–726.
• Zelitch I "The isolation and action of crystalline glyoxylic acid reductase from tobacco leaves". J. Biol. Chem. 216 553–575.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes