, glycoprotein IIb/IIIa
, also gpIIb/IIIa
, is an integrin
found on platelets
. Calcium-dependent association of gpIIb and gpIIIa is required for normal platelet aggregation and endothelial adherence.
Defects in glycoprotein IIb/IIIa causes Glanzmann's thrombasthenia
Glycoprotein IIb/IIIa inhibitors
can be used to prevent blood clots in an effort to decrease the risk of heart attack