glycerol + NAD⁺ $rightleftharpoons$ glycerone + NADH + H⁺

Thus, the two substrates of this enzyme are glycerol and NAD⁺, whereas its three products are glycerone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycerol:NAD+ 2-oxidoreductase. Other names in common use include glycerin dehydrogenase, and NAD+-linked glycerol dehydrogenase. This enzyme participates in glycerolipid metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .

See also

• Glycerol dehydrogenase (NADP+)
• Glycerol dehydrogenase (acceptor)

References

• ASNIS RE, BRODIE AF "A glycerol dehydrogenase from Escherichia coli". J. Biol. Chem. 203 153–9.
• Burton RM and Kaplan NO "A DPN specific glycerol dehydrogenase from Aerobacter aerogenes". J. Am. Chem. Soc. 75 1005–1007.
• Lin ECC and Magasanik B "The activation of glycerol dehydrogenase from Aerobacter aerogenes by monovalent cations". J. Biol. Chem. 235 1820–1823.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes