This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:L-cysteine gamma-ligase (ADP-forming). Other names in common use include gamma-glutamylcysteine synthetase, gamma-glutamyl-L-cysteine synthetase, and gamma-glutamylcysteinyl synthetase. This enzyme participates in glutamate metabolism and glutathione metabolism. At least one compound, [[S-Butyl-DL-homocysteine-[S,R]-sulfoximine]] is known to inhibit this enzyme.
Decreased Whole-Body and Splanchnic Glutamate Metabolism in Healthy Elderly Men and Patients with Chronic Obstructive Pulmonary Disease in the Postabsorptive State and in Response to Feeding1
Sep 01, 2005; ABSTRACT Decreased plasma and muscle glutamate concentrations have been observed in patients with chronic obstructive pulmonary...