D-gluconate + NAD(P)+ $rightleftharpoons$ 5-dehydro-D-gluconate + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-gluconate, NAD⁺, and NADP⁺, whereas its 4 products are 5-dehydro-D-gluconate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NAD(P)+ 5-oxidoreductase. Other names in common use include 5-keto-D-gluconate 5-reductase, 5-keto-D-gluconate 5-reductase, 5-ketogluconate 5-reductase, 5-ketogluconate reductase, and 5-keto-D-gluconate reductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Ameyama M and Adachi O "5-Keto-D-gluconate reductase from Gluconobacter suboxydans". Methods Enzymol. 89 198–202.
• Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6 2726–32.
• Okamoto K "Enzymic studies on the formation of 5-ketogluconic acid by Acetobacter suboxydans. II. 5-Ketogluconate reductase". J. Biochem. 448.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes