The epithelium of the glans penis is mucocutaneous tissue. Birley et al. report that excessive washing with soap may dry the mucous membrane that covers the glans penis and cause non-specific dermatitis.
Inflammation of the glans penis is known as balanitis. It occurs in 3–11% of males, and up to 35% of diabetic males. It has many causes, including irritation, or infection with a wide variety of pathogens. Careful identification of the cause with the aid of patient history, physical examination, swabs and cultures, and biopsy are essential in order to determine the proper treatment.
The foreskin maintains the mucosa in a moist environment. In males who have been circumcised, but have not undergone restoration, the glans is permanently exposed and dry. Szabo and Short found that the glans of the circumcised penis does not develop a thicker keratinization layer. Studies have suggested that the glans is equally sensitive in circumcised and uncircumcised males.
Halata & Munger (1986) report that the density of genital corpuscles is greatest in the corona glandis, while Yang & Bradley (1998) report that their study "showed no areas in the glans to be more densely innervated than others."
Halata & Spathe (1997) reported that "the glans penis contains a predominance of free nerve endings, numerous genital end bulbs and rarely Pacinian and Ruffinian corpuscles. Merkel nerve endings and Meissner's corpuscles are not present."
Yang & Bradley argue that "The distinct pattern of innervation of the glans emphasizes the role of the glans as a sensory structure".
An anatomycal variant of glans is showed: Hirsuties papillaris genitalis