A genetic disorder
is a condition caused by abnormalities in genes
. While some diseases, such as cancer
, are due to genetic abnormalities acquired in a few cells during life, the term "genetic disease" most commonly refers to diseases present in all cells of the body and present since conception
. Some genetic disorders are caused by chromosomal abnormalities
due to errors in meiosis
, the process which produces reproductive cells such as sperm
. Examples include Down syndrome
(extra chromosome 21), Turner Syndrome
(45Xo) and Klinefelter's syndrome
(a male with 2 X chromosomes). Other genetic changes may occur during the production of germ cells by the parent. One example is the triplet expansion repeat mutations which can cause fragile X syndrome
or Huntington's disease
. Defective genes may also be inherited intact from the parents. This can often happen unexpectedly when two healthy carriers of a defective recessive gene
reproduce, but can also happen when the defective gene is dominant
Currently about 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. Cystic fibrosis is one of the most common genetic disorders; around 5% of the population of the United States carry at least one copy of the defective gene. Some types of recessive gene disorder confer an advantage in the heterozygous state in certain environments.
Genetic diseases are typically diagnosed and treated by geneticists. Genetic counselors assist the physicians and directly counsel patients. The study of genetic diseases is a scientific discipline whose theoretical underpinning is based on population genetics.
Single gene disorders
Where genetics are the result of a single mutated gene they can be passed on to subsequent generations in several ways. Genomic imprinting
and uniparental disomy
, however, may affect inheritance patterns. The divisions between recessive and dominant are not "hard and fast" although the divisions between autosomal and X-linked are (related to the position of the gene). For example, achondroplasia
is typically considered a dominant disorder, but children with two genes for achondroplasia have a severe skeletal disorder that achondroplasics could be viewed as carriers of. Sickle-cell anemia
is also considered a recessive condition, but carriers that have it by half along with the normal gene have increased immunity to malaria in early childhood, which could be described as a related dominant condition.
Only one mutated copy of the gene will be necessary for a person to be affected by an autosomal dominant disorder. Each affected person usually has one affected parent. There is a 50% chance that a child will inherit the mutated gene. Conditions that are autosomal dominant have low penetrance
, which means that, although only one mutated copy is needed, a relatively small proportion of those who inherit that mutation go on to develop the disease, often later in life. Examples of this type of disorder are Huntington's disease
, Neurofibromatosis 1
, Marfan Syndrome
, Hereditary nonpolyposis colorectal cancer
, and Hereditary multiple exostoses
,which is a high penetrance autosomal dominant disorder.
Two copies of the gene must be mutated for a person to be affected by an autosomal recessive disorder. An affected person usually has unaffected parents who each carry a single copy of the mutated gene (and are referred to as carriers). Two unaffected people who each carry one copy of the mutated gene have a 25% chance with each pregnancy of having a child affected by the disorder. Examples of this type of disorder are Cystic fibrosis
, Sickle cell anemia
(Also Partial Sickle Cell Anemia), Tay-Sachs disease
, Spinal muscular atrophy
, and Dry (otherwise known as "rice-brand") earwax
X-linked dominant disorders are caused by mutations in genes on the X chromosome
. Only a few disorders have this inheritance pattern. Males are more frequently affected than females, and the chance of passing on an X-linked dominant disorder differs between men and women. The sons of a man with an X-linked dominant disorder will not be affected, and his daughters will all inherit the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each pregnancy. Some X-linked dominant conditions, such as Aicardi Syndrome
, are fatal to boys, therefore only girls have them (and boys with Klinefelter Syndrome
). Other examples of this type of disorder are X-linked hypophosphatemia
(hypophosphatemic rickets, vitamin D-resistant rickets), Aicardi Syndrome
, Chokenflok syndrome
and Rett's syndrome
X-linked recessive disorders are also caused by mutations in genes on the X chromosome. Males are more frequently affected than females, and the chance of passing on the disorder differs between men and women. The sons of a man with an X-linked recessive disorder will not be affected, and his daughters will carry one copy of the mutated gene. With each pregnancy, a woman who has an X-linked recessive disorder (Xr
) has a 50% chance of having sons who are affected and a 50% chance of having daughters who carry one copy of the mutated gene.Examples of this type of disorder Hemophilia A
, Duchenne muscular dystrophy
, Color blindness
, Muscular dystrophy
and Androgenetic alopecia
Y-linked disorders are caused by mutations on the Y chromosome. Only males can get them, and all of the sons of an affected father are affected. Since the Y chromosome is very small, Y-linked disorders only cause infertility, and may be circumvented with the help of some fertility treatments. Examples are Male Infertility
and hypertrichosis pinnae.
This type of inheritance, also known as maternal inheritance, applies to genes in mitochondrial DNA
. Because only egg cells contribute mitochondria to the developing embryo, only females can pass on mitochondrial conditions to their children. Examples of this type of disorder are Human mitochondrial genetics
, and Leber's Hereditary Optic Neuropathy
Multifactorial and polygenic disorders
Genetic disorders may also be complex, multifactorial or polygenic, this means that they are likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. Multifactoral disorders include heart disease
. Although complex disorders often cluster in families, they do not have a clear-cut pattern of inheritance. This makes it difficult to determine a person’s risk of inheriting or passing on these disorders. Complex disorders are also difficult to study and treat because the specific factors that cause most of these disorders have not yet been identified.
On a pedigree, polygenic diseases do tend to “run in families”, but the inheritance does not fit simple patterns as with Mendelian diseases. But this does not mean that the genes cannot eventually be located and studied. There is also a strong environmental component to many of them (e.g., blood pressure).