Gautamiputra Satakarni, often acknowledged by historians as the greatest of the Satavahana rulers, took to the throne after his father, Satakarni. Satakarni had earlier expanded the Satavahana Empire and gained considerable prosperity due to his two Aswamedha sacrifices. However, when Gautamiputra ascended the throne, the Satavahana Empire was loosely attached and was facing the threats of invasions from Sakas and Yavanas. However, Gautamiputra defeated the Yavanas, Sakas and Pahlavas and re-established the ancient glory of the Satavahanas. He overthrew Nahapana and restruck a large number of Ksaharata coins of the Jogalthembi hoard.
The Nasik Prasasti describes Gautamiputra as the ruler of the Aparanta, Anupa, Saurashtra, Kukura, Akara and Avanti, and he must have wrested them from Nahapana. He also seems to have recovered the territories in Central Deccan, which had been lost by the Satavahanas during the earlier rule of his predecessors. Under him, the Satavahana arms must have reached as far south as Kanchi. He is also credited with the conquest of territories in the Kolhapur area in the Southern Maharashtra, which he seized from the Ananda rulers. Gautamiputra also annexed the Banavasi area, thus established his sway over portions of Karnataka. He was succeeded by his son, Vasisthiputra Sri Pulamavi in about 130 AD.
Gautamiputra Satakarni took the titles of
| Preceded by:|
| Satavahana ruler|
| Succeeded by:|
Vasisthiputra Sri Pulamavi