The Gattermann-Koch reaction
, named for the German chemists Ludwig Gattermann
and Julius Arnold Koch
, in organic chemistry
refers to a Friedel-Crafts acylation
reaction in which carbon monoxide
and hydrochloric acid are used in-situ
with Friedel-Crafts catalyst
, namely AlCl3
to produce a benzaldehyde
-derivative from a benzene-derivative in one step. Benzaldehyde and many aromatic aldehydes
are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride
are also needed.
An example would be the conversion of toluene to p-tolualdehyde.