Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a human gene.

Subtype selective ligands

Recent research has produced several ligands which are moderately selective for GABA_A receptors containing the α₅ subtype. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subtype have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.

Agonists

• QH-ii-066

Inverse agonists

• α5IA
• L-655,708

See also

• GABAA receptor

References

Further reading

External links