In 1774, Salvador was chosen to be a delegate to the revolutionary Provincial Congress of the colony, which first met in Charleston in January 1775. The group framed a bill of rights and composed an address to South Carolina's royal governor setting forth the colonists' complaints against the Crown. Salvador was appointed to a commission which negotiated with the Tories in the northern and western parts of the colony. The commission's primary goal was to ensure that these colonists would not actively aid the English crown.
The second Provincial Congress assembled in November of 1775, and Salvador pressed for its members to instruct the colony's delegation to the Continental Congress to cast their vote for independence. Salvador chaired the ways and means committee of this second Congress, at the same time serving on a select committee authorized to issue bills of credit as payment to members of the militia. He was also made part of a commission established to preserve the peace in the interior parts of South Carolina.
The Cherokee may have just organized the ambush, when they learned of the approaching army, to defend their towns. They were defeated and their towns burned.
On the morning of August 1, Salvador was shot by a Cherokee. He was discovered after falling into some bushes, and was promptly scalped. He died, aged twenty-nine.
Concerning his death, Colonel William Thomson wrote to William Henry Drayton, in a letter dated "Camp, two miles below Keowee, August 4th, 1775", as follows: "Here, Mr. Salvador received three wounds; and, fell by my side...I desired [Lieutenant Farar], to take care of Mr. Salvador; but, before he could find him in the dark, the enemy unfortunately got his scalp: which, was the only one taken...He died, about half after two o'clock in the morning: forty-five minutes after he received the wounds, sensible to the last. When I came up to him, after dislodging the enemy, and speaking to him, he asked, whether I had beat the enemy? I told him yes. He said he was glad of it, and shook me by the hand – and bade me farewell – and said, he would die in a few minutes." Reference, "Documentary History of the American Revolution: Consisting of Letters and Papers Relating to the Contest for Liberty, Chiefly in South Carolina. (Vol. 1)" by Robert Wilson Gibbes, pp. 125-127. By November of 1775, Francis Salvador had alreay died in the above described events. If he did urge independence, as was probable at the time, it must have been at an earlier date.
As a side note, Salvador probably never learned that the delegation in Philadelphia had heeded his advice and voted for independence.