Straight historical drama has been one of the younger Quinn’s strengths, playing roles such as that of Latino Captain Salamanca in Steven Spielberg’s mini-series Into the West (2005) and a lead role in TNT's Rough Riders (1997) (TV). One of Quinn’s earliest roles was as Marcus Vinicius in the 1985 mini-series Quo Vadis?.
Francesco has appeared in 23 feature films including the New York Independent Film Festival winner Placebo Effect. He starred with his famous father in several films, including A Star For Two with Lauren Bacall. One of their most poignant performances together was in The Old Man and the Sea, playing Santiago as a young man opposite his father as the elder version. More recent examples displaying his acting range have also been Park, which won the coveted audience award at 2007 CineVegas, and the poignant short film Muertas, starring America Ferrera.
Meanwhile, some of Francesco Quinn’s most extensive and effective work has been in television guest star roles in crime and thriller dramas. He was lead guest star in an episode of JAG (1995) that won the show a 29 share (the highest rating in its history). On CBS’s The Fugitive, Quinn played Victor Gutierrez, a DEA agent with an edge, and he has played recurrent villain Syed Ali on Fox’s series 24. Other TV guest starring roles have occurred in Criminal Minds, ER, , Navy NCIS, Alias, Crossing Jordan, In the Heat of the Night, Miami Vice, Red Shoe Diaries, The Handler, Soldier of Fortune, Good vs. Evil, Vengeance Unlimited, and The Adventures of Young Indiana Jones.
Francesco was a longtime fixture on CBS's hottest soap, Young and the Restless and was nominated for an ALMA Award as Outstanding Actor in a Daytime Soap Opera for his work as Tomas Del Cerro, an aloof writer from New York.
Quinn was one of the earlier working actors to branch out into contributing to video games with his role as a main character in Command & Conquer: Tiberian Sun (1999).
He has been married to Irish American Julie McCann, who is the niece of the Belfast Snooker legend Alex Higgins, since 1992, whom he refers to as the "love of his life and soul mate". They reside in Sherman Oaks, California with his twin children Max and Michela, who were baptized by the late Pope John Paul II.
Quinn was a contestant on Ty Murray’s Celebrity Bull Riding Challenge on CMT, until he was sidelined with a broken rib after being stomped on by a Level 2 bull.