In music:

• Fragile (Yes album), an album by Yes released in 1971
• Fragile (Dead or Alive album), an album by Dead or Alive released in 2000
• Fragile (Saron Gas album), an album by Saron Gas released in 2000
• The Fragile, an album by Nine Inch Nails released in 1999
• Fragile (song), a song composed by Sting
• Fragile Recordings, a record label

In film:

• Fragile (2005 film), a film by Jaume Balagueró
• Fragile (2006 film), a drama by Fredric Lean starring Sheree Wilson (Cannes 2006)

in video games:

• Fragile: Sayonara Tsuki no Haikyo, a Japanese role playing game for the Wii