Fluacizine (INN) is an antidepressant with sedative properties derived from phenothiazine.
Fluacizine possesses strong central and peripheral anticholinergic activity.
Fluacizine is indicated in bipolar depression
, the emotional problems accompanying schizophrenia
, anxiety accompanying depression, and for the depressive and extrapyramidal
symptoms resulting from neuroleptic
therapy. It is not effective for atypical depression
or late-onset depression
(once known as involutional melancholia
Side effects of fluacizine include feeling of weakness, nausea, and dry mouth.
Fluacizine is contraindicated in patients with liver or kidney impairment, enlarged prostate
, peptic ulcer
or who have taken MAOIs
less than 14 days before starting therapy.