Fibulin-1 is a calcium-bindng glycoprotein. In vertebrates, fibulin-1 is found in blood and extracellular matrices. In the extracellular matrix, fibulin-1 associates with basement membranes and elastic fibers. Association with these matrix structures is mediated by its ability to interact with numerous extracellular matrix constituents including fibronectin, proteoglycans, laminins and tropoelastin. In blood, fibulin-1 associates with fibrinogen.

Genes

• FBLN1, FBLN2, FBLN5

External links

• Argraves WS, Tran H, Burgess WH, Dickerson K (1990). "Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure". J. Cell Biol. 111 (6 Pt 2): 3155–64.