Spoonman (1999) a film about reality principles explored through the life of a heroin dependent was Asemota's first work. FiTH WORK (1999-) is an on-going series with which he evolves a language for his ideas. FiTH is an acronym coined in 1999 by him meaning fever in the head. The works from the series are unique not only in form and approach but also because there are no multiples.
One of his best known works is the year-long photographic study Map of a City(2001). Asemota started the project on January 1 2001 travelling indiscriminately across London City in search of the site-specific Witness Appeal boards installed by the city's Police Force in an appeal for witnesses to numerous crimes. Images from the study were published in a controversial limited edition booklet by London Borough of Camden and featured in the premiere issue of the arts journal Magnet, which was published by Institute of International Visual Arts(inIVA) and launched at Venice Biennale in 2001.
The first work from a proposed series of three to feature Leo Asemota as a central character was The Cure Complete Works(2003). Leo Asemota is currently developing The Ens Project, the second in the series. He has also received awards and grants from Artsadmin and London Arts.
In 2004, Asemota was one of fourteen artists profiled in the book Performing Difference, published by Artsadmin. ISBN 0-9524337-2-9
On invitation from Lisa Goldman, artistic director of award winning theatre company The Red Room, Asemota created video installations and a portfolio of photographic portraits of Hoxton residents for the site-specific production Hoxton Story which opened at Hoxton Hall, to sold out performances on September 10, 2005.