The white adipose tissue is used as a store of energy. Upon release of insulin from the pancreas, white adipose cells' insulin receptors cause a dephosphorylation cascade that lead to the inactivation of hormone-sensitive lipase. Upon release of glucagon from the pancreas, glucagon receptors cause a phosphorylation cascade that activates hormone-sensitive lipase, causing the breakdown of the stored fat to fatty acids, which are exported into the blood and bound to albumin, and glycerol, which is exported into the blood freely. Fatty-acids are taken up by muscle and cardiac tissue as a fuel source, and glycogen is taken up by the liver for gluconeogenesis. White adipose tissue also acts as a thermal insulator, helping to maintain body temperature.
Response to Intra- and Extracellular Lipolytic Agents and Hormone-Sensitive Lipase Translocation Are Impaired in Adipocytes from Rats Adapted to a High-Protein, Carbohydrate-Free Diet1
Nov 01, 2004; ABSTRACT We showed previously that rats adapted to a high-protein (70 carbohydrate-free (HP) diet have reduced lipolytic...