In Grand Prix motorcycle racing, which includes the 80cc, 125cc, 250cc, 350cc, and 500cc/MotoGP classes, no point is awarded for the fastest lap. Giacomo Agostini holds the current record for the most fastest laps with 117. Valentino Rossi, who still actively races in MotoGP, is in fourth place with 75 fastest laps.
| Place | Driver | Fastest laps |
|---|---|---|
| 1 | Michael Schumacher | 76 |
| 2 | Alain Prost | 41 |
| 3 | Kimi Räikkönen | 35 |
| 4 | Nigel Mansell | 30 |
| 5 | Jim Clark | 28 |
| 6 | Mika Häkkinen | 25 |
| 7 | Niki Lauda | 24 |
| 8= | Juan Manuel Fangio | 23 |
| 8= | Nelson Piquet | 23 |
| 10 | Gerhard Berger | 21 |
| Place | Rider | Fastest laps |
|---|---|---|
| 1 | Giacomo Agostini | 117 |
| 2 | Ángel Nieto | 81 |
| 3 | Mike Hailwood | 79 |
| 4 | Valentino Rossi | 77 |
| 5 | Michael Doohan | 46 |
| 6 | Max Biaggi | 42 |
| 7 | Phil Read | 36 |
| 8 | Jim Redman | 35 |
| 9= | John Surtees | 34 |
| 9= | Carlo Ubbiali | 34 |