Definitions

Factor II

Transcription Factor II D

Transcription Factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIID is itself composed of several subunits called TBP-associated factors (TAFs, of which there are 14) and the TATA Binding Protein (TBP).

In a test tube, only TBP is necessary for transcription at promoters that contain a TATA box. TAFs, however, add promoter selectivity, especially if there is no TATA box sequence for TBP to bind to.

Subunits in the TFIID complex include:

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