FAD-AMP lyase (cyclizing)

FAD-AMP lyase (cyclizing)

In enzymology, a FAD-AMP lyase (cyclizing) is an enzyme that catalyzes the chemical reaction

FAD rightleftharpoons AMP + riboflavin cyclic-4',5'-phosphate

Hence, this enzyme has one substrate, FAD, and two products, AMP and riboflavin cyclic-4',5'-phosphate.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming). Other names in common use include FMN cyclase, and FAD AMP-lyase (cyclic-FMN-forming).


  • Cameselle JC "Enzymic formation of riboflavin 4',5'-cyclic phosphate from FAD: evidence for a specific low-Km FMN cyclase in rat liver1". Biochem. J. 330 881–8.
  • Cameselle JC "Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion". Biochemistry. 40 13710–22.

External links

The CAS registry number for this enzyme class is .

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