Excitatory amino acid transporter 2

Polar-amino-acid-transporting ATPase

In enzymology, a polar-amino-acid-transporting ATPase is an enzyme that catalyzes the chemical reaction

ATP + H2O + polar amino acidout rightleftharpoons ADP + phosphate + polar amino acidin

The 3 substrates of this enzyme are ATP, H2O, and polar amino acid, whereas its 3 products are ADP, phosphate, and polar amino acid.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (polar-amino-acid-importing). This enzyme is also called histidine permease. This enzyme participates in abc transporters - general.


  • Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146 271–8.
  • Saier MH Jr "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40 81–136.
  • Nikaido K, Liu PQ, Ames GF "Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity". J. Biol. Chem. 272 27745–52.
  • Walshaw DL, Lowthorpe S, East A, Poole PS "Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity". FEBS. Lett. 414 397–401.

External links

Gene Ontology (GO) codes

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