is a bacteriostatic antimycobacterial drug
prescribed to treat tuberculosis
). It is usually given in combination with other tuberculosis drugs
, such as isoniazid
It is sold under the name "Myambutol".
against actively growing TB bacilli, it works by obstructing the formation of cell wall
. Mycolic acids
attach to the 5'-hydroxyl groups of D-arabinose
residues of arabinogalactan
and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. It disrupts arabinogalactan synthesis by inhibiting the enzyme arabinosyl transferase
. Disruption of the arabinogalactan synthesis inhibits the formation of this complex and leads to increased permeability of the cell wall.
It is well absorbed from the gastrointestinal tract
and well distributed in body tissues and fluids, 50% is excreted unchanged in urine.