(also known as Epoxide hydratase) functions in detoxication
during drug metabolism
It converts epoxides from the degradation of aromatic
compounds to trans-dihydrodiols which can be conjugated and excreted from the body.
Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.