People

• Epigenes of Athens, an Ancient Greek comic poet
• Epigenes of Byzantium, an Ancient Greek astrologer
• Epigenes of Sicyon, an Ancient Greek tragedist
• Epigenes, son of Antiphon, a disciple of Socrates

Other

• Epigenes (biology), a concept in biology
• Epigenes (crater), a lunar crater named after the astrologer