On February 26, 2000, O'Sheas made the 2001 Edition of the Guinness Book of World Records by having 220 patrons contribute to the largest crowd to participate in a nationwide toast. The Great Guinness Toast, as it is called, was tallied nationwide as having 320,470 participants. That easily broke the previous year's record of 197,846 participants.
In 2006, Vince Neil, lead singer of the band Mötley Crüe, opened Vince Neil Ink, a tattoo parlor inside of O'Sheas. It features a room called "The Stage" that is visible from the Las Vegas Strip, so you can watch the tattoo artists work from outside.
According to the casino's announcement system, O'Sheas has the only Burger King restaurant on The Strip inside the casino. There is however one other Burger King, located just south of Charleston Blvd on Las Vegas Blvd, approximately four miles away. O'Shea's targets, and typically draws, a younger crowd in its 20s and early 30s. The casino offers low minimums on table games, a poker room, and beer pong tables. Before being purchased by Harrah's, O'Sheas branded itself as having low minimums and liberal rules on table games, thus attempting to draw "locals" and savvy, low-minimum gamblers. Since acquisition by Harrah's, O'Sheas has generally offered the least advantageous table games in Nevada (i.e., bad for players), especially on Blackjack (where Blackjack only pays 6:5 on all games), and has branded itself as a "party" casino in the heart of the Strip.