Ekwok is on the Nushagak River in southwestern Alaska, 69 km (43 miles) northeast of Dillingham.
According to the United States Census Bureau, the city has a total area of 17.3 square miles (44.9 km²), of which, 16.0 square miles (41.4 km²) of it is land and 1.4 square miles (3.5 km²) of it (7.85%) is water.
There were 42 households out of which 47.6% had children under the age of 18 living with them, 61.9% were married couples living together, 7.1% had a female householder with no husband present, and 28.6% were non-families. 28.6% of all households were made up of individuals and 4.8% had someone living alone who was 65 years of age or older. The average household size was 3.10 and the average family size was 3.93.
In the city the population was spread out with 43.8% under the age of 18, 3.8% from 18 to 24, 26.2% from 25 to 44, 19.2% from 45 to 64, and 6.9% who were 65 years of age or older. The median age was 32 years. For every 100 females there were 113.1 males. For every 100 females age 18 and over, there were 114.7 males.
The median income for a household in the city was $16,250, and the median income for a family was $20,000. Males had a median income of $38,750 versus $35,750 for females. The per capita income for the city was $11,079. There were 29.2% of families and 32.1% of the population living below the poverty line, including 24.4% of under eighteens and 40.0% of those over 64.
From the early 1900s until 1941, mail was delivered by dog sled from Dillingham. in 1941 a post office opened in Ekwok. Before 1960, most of the buildings in Ekwok were located in a low area near the river. After a flood in the early 1960s, the village was relocated to its current location.