Ekwendeni is a town about 20km from Mzuzu, in the Mzimba district of Malawi. It is one of the busiest (and largest) towns in the Northern Region of Malawi. Ekwendeni was started by Scottish missionaries. It has one of the oldest churches in Malawi belonging to the Malawi equivalent of the Church of Scotland.
Ekwendeni is largely surrounded by tobacco growing farms. It has one of the highest HIV/AIDS prevalence rates in Malawi mainly because it is a favourite resting place for truck drivers travelling between Malawi and its northern neighbour, Tanzania, Kenya and beyond.
Ekwendeni has a hospital run by the presbyterian church with the bulk of the funding coming from the United States and Scotland. The people of Ekwendeni have Tumbuka as the dominant language but other languages are spoken due to the high numbers of people from other parts of Malawi settling there.Ekwendeni has a college of nursing, college of commerce,and technical training school.