- EPA and its metabolites act in the body largely by their interactions with the metabolites of arachidonic acid; see Essential fatty acid interactions for detail.
Sources
It is obtained in the human diet by eating oily fish or fish oil—cod liver, herring, mackerel, salmon, menhaden and sardine. It is also found in human breast milk.However, fish do not naturally produce EPA, but obtain it from the algae they consume. It is available to humans from some non-animal sources (eg, commercially, from spirulina and microalgae). Microalgae are being developed as a commercial source. EPA is not usually found in higher plants, but it has been reported in trace amounts in purslane. Microalgae, and supplements derived from it, are excellent alternative sources of EPA and other fatty acids, since fish often contain toxins due to pollution.
The human body can (and in case of a purely vegetarian diet often must, unless the aforementioned algae or supplements derived from them are consumed) also convert α-linolenic acid (ALA) to EPA, but this is much less efficient than the resorption of EPA from food containing it, and ALA is itself an essential fatty acid, an appropriate supply of which must be ensured. Because EPA is also a precursor to docosahexaenoic acid (DHA), ensuring a sufficient level of EPA on a diet containing neither EPA nor DHA is harder both because of the extra metabolic work required to synthesize EPA and because of the use of EPA to metabolize DHA. Medical conditions like diabetes or certain allergies may significantly limit the human body's capacity for metabolization of EPA from ALA.
Clinical significance
The US National Institute of Health's MedlinePlus lists a large number of conditions in which EPA (alone or in concert with other ω-3 sources) is known or thought to be effective. Most of these involve its ability to lower inflammation.Among omega-3 fatty acids, in particular EPA is thought to possess beneficial potential in mental conditions, such as schizophrenia. Several studies report an additional reduction in scores on symptom scales used to assess the severity of symptoms, when additional EPA is taken.
Recent studies have suggested that EPA may affect depression, and importantly, suicidal behavior. One such study, took blood samples of 100 suicide-attempt patients and compared the blood samples to those of controls and found that levels of Eicosapentaenoic acid were significantly lower in the washed red blood cells of the suicide-attempt patients.
EPA has inhibitory effect on CYP2C9 and CYP2C19 hepatic enzymes. At high dose, it may also inhibit the activity of CYP2D6 and CYP3A4, important enzymes involved in drug metabolism.
See also
- Chlorella
- Cyanobacteria
- Docosahexaenoic acid
- List of omega-3 fatty acids
- Polyunsaturated fatty acids
- Snake oil
- Wakame
References
This article is licensed under the GNU Free Documentation License.
Last updated on Tuesday September 09, 2008 at 09:21:03 PDT (GMT -0700)
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