Edwin Ruthven Holmes
- December 10
) was a United States federal judge
Born in Sidon, Mississippi, he graduated from the University of Mississippi in 1899.
Holmes had a private law practice in Yazoo City, Mississippi from 1900 to 1918 and was mayor of Yahoo City from 1904 to 1908.
On October 17, 1918, President Woodrow Wilson nominated Holmes to the United States district court in the Northern and Southern districts of Mississippi. He was confirmed on October 24, 1918.
During his time as a district court judge, he earned the ire of former Governor of Mississippi Theodore Bilbo by sentencing him to thirty days in jail for contempt of court.
President Franklin D. Roosevelt nominated Holmes to the United States Court of Appeals for the Fifth Circuit on August 23, 1935. He was confirmed on March 19, 1936, with only Bilbo voting against his confirmation. He served as a judge until his death.