Edward B. Lewis

Edward B. Lewis

Lewis, Edward B., 1918-2004, American geneticist, b. Wilkes-Barre, Pa., grad. California Institute of Technology (Ph.D. 1942). After serving as a meteorologist with the U.S. Army Air Corps during World War II, he returned to the California Institute of Technology and taught there until he retired in 1988. In studying a four-winged mutant fruit fly, he identified the genes regulate the development of the fly's body segments and discovered that the arrangment of the genes in the DNA strand mimicked the arrangement of the body segments, a condition that is now known as the colinearity principle. For this work he shared the 1995 Nobel Prize in Physiology or Medicine with Eric F. Wieschaus and Christiane Nüsslein-Volhard. In the 1950s Lewis also investigated the effects of radiation and showed that exposure to low doses of X rays and other radiation sources involves greater risk than had been believed.

(born May 20, 1918, Wilkes-Barre, Pa., U.S.—died July 21, 2004, Pasadena, Calif.) U.S. geneticist. He received a Ph.D. (1942) in genetics from the California Institute of Technology, where he taught from 1946 to 1988. By crossbreeding thousands of fruit flies, he discovered that genes are arranged on the chromosome in the order corresponding to body segments, an orderliness now known as the colinearity principle. Lewis's work helped explain mechanisms of general biological development, including the causes of deformities present at birth in humans. With Christiane Nüsslein-Volhard and Eric F. Wieschaus, he was awarded a 1995 Nobel Prize.

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Edward B. Lewis (May 20, 1918July 21, 2004) was an American geneticist, the winner of the 1995 Nobel Prize in Medicine.

Lewis was born in Wilkes-Barre, Pennsylvania and graduated from E.L. Meyers High School. He received a BA in Biostatistics from the University of Minnesota in 1939, where he worked on Drosophila melanogaster in the lab of C.P. Oliver. In 1942 Lewis received a Ph.D. from California Institute of Technology (Caltech), working under the guidance of Alfred Sturtevant. After serving as a meteorologist in the U.S. Air Force in World War II, Lewis joined the Caltech faculty in 1946 as an instructor. In 1956 he was appointed Professor of Biology, and in 1966 the Thomas Hunt Morgan Professor of Biology. Among his many awards were the Thomas Hunt Morgan Medal (1983), the Gairdner Foundation International award (1987), the Wolf Foundation prize in medicine (1989), the Rosenstiel award (1990), the National Medal of Science (1990), the Albert Lasker Award for Basic Medical Research (1991), and the Louisa Gross Horwitz Prize (1992).

His Nobel Prize winning studies with Drosophila founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. He is credited with development of the complementation test. His key publications in the fields of genetics, developmental biology, radiation and cancer are presented in the book Genes, Development and Cancer, which was released in 2004.


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