From the city centre to Banner Cross the road is home to many pubs and student accommodation. In the suburb of Ecclesall, one of the UK's wealthiest districts, the road is bordered by rather large properties.
Ecclesall Road is itself noted for its vast range of restaurants, pubs, bars cafes and shops, including many one-off boutiques. The Ecclesall Road shopping area (formally known as Endcliffe Market) is mostly on the South side of the road, and also includes Hunters Bar and Sharrow Vale Road. As the road nears the City Centre, there is a large car showroom, gym and a Waitrose supermarket. The North side of the road is residential, containing the Hannover Flats and the districts of Broomhall, The Groves and Ranmoor. It has a large student population (mostly from Sheffield Hallam University) although there are some flats owned by the University of Sheffield. The road also runs past Endcliffe Park and close to Ecclesall Woods.
Ecclesall Road was constructed in the early part of the 19th century, and was operated as a turnpike road by the Sheffield and Chapel en le Frith Trust—the first toll being paid at Hunter's Bar. The tolls were abolished on 31 October 1884 and the toll house at Hunter's Bar was demolished, although the gate posts were preserved and are now situated in the centre of Hunters Bar roundabout. In the early part of the 20th century the road was used by one of the city's tramway lines, terminating at the top of Woodholm Road. This was one of the first tram routes to close, being abandoned in March 1954 despite a petition against its closure of 11,000 signatures. The starting point of Ecclesall Road was originally at the junction of London Road and Cemetery Road, however the road was truncated at Moore Street when Sheffield's Inner Ring was constructed in the 1960s.