Previously, the area was part of the Rumeli eyalet.
The vilayet was bounded on the south by the Aegean Sea, and by the vilayet of Edirne (Adrianople) on the east, the vilayet of Eastern Roumelia on the northeast (after the Treaty of Berlin), the Principality, then Kingdom, of Bulgaria on the north, the vilayet of Kosovo on the northwest, and the vilayet of Monastir and the independent sanjak of Serfije on the west (after 1881). The vilayet was consisted from present Central and Eastern parts of Greek Macedonia and Pirin Macedonia in Bulgaria. Present Pirin Macedonia part of her was administrated as kazas of Cuma-yı Bala, Petriç, Nevrekop and Razlık. She was dissolved after Balkan Wars and divided to Kingdom of Greece and Tsardom of Bulgaria in 1913.