The ERM protein family
consists of three closely-related proteins
ERM molecules contain the following three domains
Ezrin, radixin and merlin also contain a polyproline region between the central helical and C-terminal domains.
ERM proteins crosslink actin
filaments with plasma membranes
. They co-localize with CD44
at actin filament-plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains.