He is also a prominent tulku associated with Dzongsar Monastery in Derge, Eastern Tibet.
The first incarnation was Jamyang Khyentse Wangpo (1820-1892), who helped found the Rimé or ecumenical school of Tibetan Buddhism. Followers of this non-sectarian school sought to identify and make use of the best methods from the various long-competing and isolated schools of Tibetan Buddhism. This approach led to a blossoming of scholarship and writing beginning in the 1880s.
The second incarnation was the renowned lama Dzongsar Khyentse Chokyi Lodro (1893-1959), who figured prominently in the export of Tantric Buddhism to the West as the root-teacher of a generation of influential and forward-thinking lamas.
A biographical portrait of Dzongsar Khyentse Rinpoche exists in documentary feature film form. The film came out in 2003, and is called Words of My Perfect Teacher after the English rendering of a famed work by Patrul Rinpoche. It is a portrait of the Vajrayana Buddhist student-teacher relationship.
From a young age he has been active for the preservation of the Buddhist teaching, establishing centres of learning, supporting practitioners, publishing books and teaching all over the world. Dzongsar Khyentse Rinpoche supervises his traditional seat of Dzongsar Monastery and its retreat centers in Eastern Tibet, as well as his new colleges in India (in Bir and Chowntra (Himachal Pradesh)) and Bhutan. He has also established centres in Australia, North America and the Far East.
In 1989, Dzongsar Khyentse Rinpoche founded Siddhartha's Intent, an international Buddhist association of non-profit centres, most of which are nationally registered societies and charities, with the principal intention of preserving the Buddhist teachings, as well as increasing an awareness and understanding of the many aspects of the Buddhist teaching beyond the limits of cultures and traditions.
In 2001 Khyentse Foundation was founded by Dzongsar Khyentse Rinpoche. It is a non-profit organization with the stated goal "to act as a system of patronage for institutions and individuals engaged in the practice and study of Buddha's wisdom and compassion.