Maria Guadalupe full name was Maria de Guadalupe de Lencastre y Cárdenas Manrique and she was the younger sister of Raimundo of Lencastre, 4th Duke of Aveiro.
There, they were quite welcomed by King Philip IV of Spain, while in Lisbon, Dom Raimundo of Lencastre, 4th Duke of Aveiro was condemn for treason (in 1663) and the King of Portugal, John IV of Portugal, confiscated the Duchy and granted it to Raimundo and Guadalupe’s uncle, Peter of Lencastre, a Braganza supporter, who was recognised as 5th Duke of Aveiro and 5th Marquis of Torres Novas.
Maria de Guadalupe married the Spanish 6th Duke of Los Arcos, Manuel Ponce de León, but it was established that the Spanish House of the Dukes of Los Arcos and the Portuguese House of the Dukes of Aveiro should remain, for ever, separated.
When the peace between Portugal and Spain was signed, Maria de Guadalupe of Lencastre requested the cancellation of the decision that granted the Duchy of Aveiro to her uncle, in order to obtain it for herself. She was recognized as 6th Duchess of Aveiro when her uncle died (1673), in the condition she would return to Portugal.
Due to her husband's opposition, she divorced him, returned to her homeland and regained the House of Aveiro and their estates. While waiting for the divorce in Spain, King Carlos II of Spain tried to avoid her return to Portugal by granting her, in 1681, the title of Duchess of Aveyro (Spanish spelling) as a Spanish title.
She had three children from her marriage with don Manuel Ponce de León: