• Desktop publishing, a technological publishing method
• Demokratik Toplum Partisi, the Turkish name for the Democratic Society Party
• Disturbing tha Peace, a hip hop act and production company
• Another name for the DPT vaccine, a triple vaccine used to inoculate against diphtheria, tetanus, and pertussis (more commonly known as whooping cough).
• Driven To Perform, a Canadian auto show tour
• Dynamic Trunking Protocol
• Distributed transaction processing, in computer systems, usually refers to the X/Open model of co-ordinating transactions between multiple participants
• Disjunctive Temporal Problem
• Draft Transit Protocol to the Energy Charter Treaty
• Data Tools Platform, which is part of the Eclipse open source community
• Diplomacy Training Program
• Developmental Therapeutics Program of the National Cancer Institute
• Direct To Pharmacy
• Digital Text Platform

DTP can also refer to

• dtp entertainment, a German computer game publisher