She attended Stanford University, where at a school dance she met Norman Chandler, eldest son of the family that had published the Los Angeles Times since 1883 and was a significant social and political force in the area. The two married in 1922, and had two children, Camilla and Otis (1927). At the time of her death in 1997, she had eight grandchildren and 14 great-grandchildren.
In 1945, her husband became publisher of the Times, a position he held until he was succeeded by their son, Otis, in 1960. Norman Chandler died in 1973, and Dorothy Chandler never remarried.
She initiated the Times Woman of the Year award, which was given to 243 women from 1950 through 1976.
In 1950, a financial crisis closed the Hollywood Bowl during its summer season. Chandler chaired a committee that organized a series of fundraising concerts that was able to reopen it, and she later served as president of its parent organization, the Southern California Symphony Association.
From this early success, she started a longer effort to build a performing arts center for Los Angeles. In 1955 she raised $400,000 at a benefit concert at the Ambassador Hotel featuring Dinah Shore, Danny Kaye and Jack Benny. This fundraiser began a nine-year crusade that raised some $20 million of the estimated $35 million total cost; the remainder was paid through private bond sales. She was featured on the cover of the December 18, 1964, issue of Time magazine, which praised her fundraising efforts as "perhaps the most impressive display of virtuoso money-raising and civic citizenship in the history of U.S. womanhood."
The Los Angeles Music Center held its first performance on December 6, 1964. The complex was completed in 1967, comprising three venues: the Dorothy Chandler Pavilion, named in honor of Dorothy Buffum Chandler, the Mark Taper Forum and the Ahmanson Theatre. The Chandler Pavilion served as the home of the Los Angeles Philharmonic from 1964 until 2003, when the Music Center opened its fourth hall, the Walt Disney Concert Hall.
On September 17, 2005 the Walt Disney Concert Hall held a Dorothy Chandler memorial concert.