Domenico Antonio Vaccaro (1678 - 1745) was an Italian painter, sculptor and architect, the son and pupil of Lorenzo Vaccaro. Lorenzo was in turn a pupil of Cosimo Fanzago and was part of a large family of artists including Andrea Vaccaro (1604-1670), a pupil of Girolamo Imparato.

Domenico Antonio was born in Naples and his body of work is all in or near that city. Works of interest include a statue of Moses in the church of San Ferdinando, and the statues of Penitence and Solitude on the premises of the monastery (now museum) of San Martino.