Discoid lupus erythematosus (DLE) is an uncommon autoimmune disease of the basal cell layer of the skin. It occurs in humans and cats, more frequently occurring in dogs. It does not progress to systemic lupus erythematosus (SLE) in dogs. SLE can also have skin symptoms, but it appears that the two are either separate diseases or DLE is a mild form of SLE. DLE in dogs differs from SLE in humans in that plasma cells predominate histologically instead of T lymphocytes. Because worsening of symptoms occurs with increased ultraviolet light exposure, sun exposure most likely plays a role in DLE, although certain breeds (see below) are predisposed, so there is probably also a genetic cause. After pemphigus foliaceus, DLE is the second most common autoimmune skin disease in dogs.
Probably the best-known human sufferer of the condition is the singer Seal, who contracted it as a child and has distinctive scars on his upper cheeks.
New discoid lupus erythematosus therapy study findings recently were reported by researchers at Shahid Beheshti University.(Clinical report)
Sep 30, 2009; New investigation results, 'Pimecrolimus 1% cream versus betamethasone 17-valerate 0.1% cream in the treatment of facial discoid...
Researchers from University of Copenhagen, Department of Dermatology report on findings in discoid lupus erythematosus therapy.
Dec 21, 2009; Scientists discuss in 'A randomized controlled trial of R-salbutamol for topical treatment of discoid lupus erythematosus' new...