Dipeptidyl peptidase-4

Dipeptidyl peptidase-4

The enzyme Dipeptidyl peptidase-4 (DPP-4) also part of the CD26 surface region is associated with immune regulation, signal transduction and apoptosis. It is a rather indiscriminate enzyme for which at least 62 substrates are known. Furthermore it appears to work as a suppressor in the development of cancer and tumours. DPP-4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPP-4 also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

Clinical significance

A new class of oral hypoglycemics called dipeptidyl peptidase-4 inhibitors work by inhibiting the action of this enzyme, thereby prolonging incretin effect in vivo.

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