Dionysius's Hermeneia (1730 - 1734) attempts to provide a synthetic (or "harmonized") Gospel account of the life of Jesus Christ. His time line and events are mainly from the Book of Matthew, but he weaves in major incidents from the other synoptic Gospels. The manual is also called Mount Athos Painter's Guide and is in three parts. In general, it is a chronological listing of scenes appropriate for painting, along with a proper inscription for the painter to include to make the icon, as well as the proper position in the church for each scene. The first part of the work gives recipes for colors, gesso, and instructions on proportion for human figure painting. The second part is a manual for the life of Christ, descriptions and inscriptions for various Biblical and hagiographic subjects, and suggested images. The third part describes the locations in a church for each depiction. The manuscript survives in more than twenty-five instances.
It is likely that Dionysius surveyed existing churches from the medieval period, where the life of Christ would be told in emblems around the church. Although the work is not original, nor designed to be original, the description of each scene is probably from Dionysius's own imagination and imagery.