Dimethylargininase

Nomega,Nomega'-methyl-L-arginine + H₂O $rightleftharpoons$ dimethylamine + L-citrulline

Thus, the two substrates of this enzyme are Nomega,Nomega'-methyl-L-arginine and H₂O, whereas its two products are dimethylamine and L-citrulline.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is Nomega,Nomega'-methyl-L-arginine dimethylamidohydrolase. Other names in common use include dimethylarginine dimethylaminohydrolase, NG,NG-dimethylarginine dimethylaminohydrolase, NG,NG-dimethyl-L-arginine dimethylamidohydrolase, and omega,omega'-di-N-methyl-L-arginine dimethylamidohydrolase.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , and .

References

• Ogawa T, Kimoto M, Sasaoka K "Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney". J. Biol. Chem. 264 10205–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes